Dr Pravin D Potdar, Faculty, Indian Dental Association Research Fellowship Program

Since completion of human genome project in 2003, several innovative technologies and instruments are introduced in the field of medicine. Next-generation sequencing (NGS) is a parallel sequencing technology which provides a large set of sequence data in very short period of time. NGS is very much useful in characterization of target identification and disease-associated mutations in drug discovery program for accurate diagnosis of various diseases. It determines the presence of drug resistance and gets better response to medical interventions. Thus, NGS is also useful in drug discovery program.

Single nucleotide polymorphisms (SNPs) are extensively used to analyze characteristics of individual who can respond to a therapeutic agent. NGS technology is useful for large-scale screening of SNPs to determine whether new drug will be effective and safe in respective individual. Large amount of genomic sequence data obtained by NGS will allow scientists to develop novel therapeutic agents by studying specific mechanism of respective disease. This is mainly important for genetic disorders which are difficult to diagnose. NGS allows us to screen and profile large number of gene mutations involved in particular diseases in short period of time and thus unique biomarkers are identified to discover drug targets. The major goal of NGS is to developed molecular targeted therapies for cancer which kill tumour cells without harming normal cell growth resulting into reduction in side effect and thus the mortality. The identification of novel molecular targets, biomarkers, and mechanistic information by NGS fastens the drug discovery process in recent year.

Recent forecast across North AmericaEuropeAsia-Pacific, and the Rest of the World, the global NGS services market is expected to be doubled in next five years. In year 2017, it is almost USD 1.059 billion and will reach to USD 2.74 billion by 2022. North America accounted for the largest share followed by Europe. Due to the rapid growth in the genomic research and NGS based diagnostics in emerging Asia-Pacific countries, like China and India, will adopt more NGS services in near future.


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