Thermo Fisher Scientific has extended its leadership in cryo-electron microscopy (cryo-EM) with the introduction of two new instruments: the Krios G3i and the Glacios cryo-transmission electron microscopes (cryo-TEMs). The new instruments, which can be used independently or together in a single particle analysis (SPA) workflow, make structural analysis of proteins, protein complexes, and other biomolecular structures faster, easier, and more accessible than ever before.

The new Krios G3i expands the industry-leading cryo-EM platform to deliver the next level of performance and productivity. Automation and ease of use have been essential in the adoption of cryo-EM in advanced structural biology research. The instruments feature important enhancements in these areas including auto-alignment, simplified user interface, and extended sample lifetime, which make the system easier to use, improve repeatability and reproducibility, and reduce time-to-results relative to previous generations.

Since its introduction nearly 10 years ago, the Krios system's ability to visualize three-dimensional (3D) structures with near-atomic resolution has enabled researchers globally to begin to unravel the complex relationships between structure and function at the molecular and atomic level. In fact, 98 percent of all structures contributed to the electron microscopy data bank (EMDB) with 4 ngstrm or better resolution and were determined using Thermo Fisher cryo-TEMs.

The new Glacios delivers a high-performance cryo-EM solution to a broader range of scientists. Leveraging the knowledge and experience of more than a decade of leadership in cryo-EM, the breakthrough Glacios extends the accessibility of cryo-EM with an industry leading price-performance. The Glacios features innovative automation for ease of use and a small footprint that simplifies installation.

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