Built on Waters proven solid-core particle technology, the CORTECS C8 and CORTECS Phenyl analytical columns are designed for scientists who need to expand chromatographic separation space while maximizing the speed, resolution, and sensitivity of their small molecule HPLC, UHPLC, or UPLC separations. Capable of operating at very high column efficiencies and low backpressures, the new columns give scientists additional selectivity choices and allow them to develop methods quickly, and generate more information with every analytical run. The chemistries are available in two particle sizes, 1.6 and 2.7 microns, and are offered in a total of 50 unique column configurations.

CORTECS C8 columns exhibit a lower hydrophobicity when compared to typical bonded C18 phases and are useful for separating strongly hydrophobic compounds. They are also ideal for chemists looking to transfer or scale compendia C8 HPLC methods to a more robust column technology. CORTECS Phenyl columns are an excellent alternative to typically bonded C18 phases, particularly for aromatic compounds, based on the unique selectivity provided by the phenyl-bonded phase. Both the 1.6 and 2.7 micron CORTECS C8 and CORTECS Phenyl columns are fully scalable for seamless transfer of methods between the two particle sizes.

The CORTECS UPLC 1.6 micron particle columns are designed to yield maximum efficiency when used with the ultra-low dispersion Waters ACQUITY UPLC instrument platform. In the separations market space, the column offers to scientists previously unattainable levels of performance.

The CORTECS 2.7 micron particle columns are designed for maximum flexibility for use on both UHPLC and HPLC instrument platforms. The column runs at lower backpressures while delivering high efficiencies, which allows for the use of longer column lengths to improve resolution or higher flow rates to speed instrument analysis times and increased throughput.

The two new chemistries complement the existing CORTECS C18+, C18, and HILIC chemistries in Waters current CORTECS product portfolio. The column particles feature a solid, impermeable silica core encased in a porous silica outer layer where interactions between the stationary phase and the analytes occur. The product of more than 40 years of bonding and surface technology know-how and a decade of synthesizing and packing sub-2-micron particle columns, Waters CORTECS columns deliver the full benefit of solid-core particle technology.


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